SafeTRANS ("Safety in Transportation Systems") is a competence cluster bringing together industrial and academic stakeholders in the domain of embedded systems in transportation (automotive, aerospace, and rail). We facilitate cooperation, identify cross-domain synergies, and enable the transfer of best practices between domains. SafeTRANS follows an integrated approach to enable secure mobility despite traffic growth and the increasing complexity of systems, by working with OEMs, suppliers, SMEs, research institutes and universities. Our activities comprise the preparation and harmonisation of R&D strategies, project incubation, technology transfer and knowledge exchange across domains (e.g. at the renowned symposium SafeTRANS Industrial Day). Furthermore, SafeTRANS supports the buildup of a Reference Technology Platform, which implements a customisable systems engineering environment, integrates existing technologies or technologies under development and facilitates their synthesis.